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Caterpillars sometimes get in amongst the spines of cacti and have a feast on the soft flesh. They are most commonly seen however on Aeoniums, where they pupate in a nest of leaves which they stick together.
Leaf edges will be chewed and their will be frass (faeces) present.
Cactus moth larvae, Cactoblastis cactorum on O. humifusa
(This should not be encountered in Europe)